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Yue Qi, Yueyi Wang, Xiaofei Wang, Hao Zheng, Yuan Lu. Tuning gut microbiota by advanced nanotechnology[J]. Materials Futures, 2025, 4(1): 012302. DOI: 10.1088/2752-5724/ada62b
Citation: Yue Qi, Yueyi Wang, Xiaofei Wang, Hao Zheng, Yuan Lu. Tuning gut microbiota by advanced nanotechnology[J]. Materials Futures, 2025, 4(1): 012302. DOI: 10.1088/2752-5724/ada62b
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Tuning gut microbiota by advanced nanotechnology

© 2025 The Author(s). Published by IOP Publishing Ltd on behalf of the Songshan Lake Materials Laboratory
Materials Futures, Volume 4, Number 1
  • Received Date: November 15, 2024
  • Revised Date: December 20, 2024
  • Accepted Date: December 29, 2024
  • Available Online: January 08, 2025
  • Published Date: January 22, 2025
DOI: 10.1088/2752-5724/ada62b

  • 1 College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, People's Republic of China;

  • 2 Department of Chemical Engineering, Tsinghua University, Beijing 100084, People's Republic of China;

  • 3 Key Laboratory of Industrial Biocatalysis, Ministry of Education, Tsinghua University, Beijing 100084, People's Republic of China

Funds: 

This work was supported by the National Natural Science Foundation of China (32170495, 22278241) and a grant from the Institute Guo Qiang, Tsinghua University (2021GQG1016).

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  • Corresponding author:

    Xiaofei Wang,E-mail:xiaofei.wang@cau.edu.cn

    Hao Zheng,E-mail:hao.zheng@cau.edu.cn

    Yuan Lu,E-mail:yuanlu@tsinghua.edu.cn

    Graphical Abstract
    • Abstract
  • Gut microbiota reveals fundamental mechanisms of health and disease, and its modulation has important applications in biomedicine. Traditional modulation methods (e.g. diet, antibiotics, and probiotics) suffer from drug resistance, poor targeting, and low efficiency. Nanotechnology has become an attractive option for the precise modulation of gut microbiota due to its targeting and controllability. This review will focus on research progress in nanotechnology to modulate gut microbiota, including the direct use of nanomaterials as antimicrobials, nano-drug delivery systems, and stimulus-responsive nanotechnology. In addition, the applications of nanotechnology to modulate gut microbiota are summarized in terms of healthcare, animal protection, and agricultural development. Finally, the challenges and corresponding solution strategies for nanotechnology modulation are reviewed, and the future development prospects for nanotechnology modulation are summarized. This review provides an important theoretical basis and practical reference for the development of gut microbiota modulation, and promotes the research and application of more precise and efficient microbiota community intervention strategies.
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